On January 2, 2025, China’s National Medical Products Administration (NMPA) granted conditional approval to Platinum Life Excellence Biotech Co. Ltd.’s amimestrocel injection (hUC-MSC PLEB-001), marking a significant milestone in the country’s medical and biotechnological advancements. The product is being marketing under the brand name Ruibosheng. This approval designates it as China’s first human umbilical cord-derived mesenchymal stem cell (hUC-MSC) therapy, offering a promising treatment option for steroid-refractory acute graft-versus-host disease (GVHD), a serious and often fatal complication following stem cell transplants. [Read more…]
Mesenchymal Stem Cells (MSCs)
Mesenchymal stem cells (MSCs) are a well-characterized population of adult stem cells that can differentiate into a variety of cell types (chondrocytes, osteoblasts, adipocytes, myocytes, and more).
MSCs for Regenerative Medicine – Serum-Free, Xeno-Free Differentiation Media
Since the discovery of mesenchymal stem cells (MSCs) by Friedenstein and his colleagues in 1976, MSCs have become one of the fastest growing areas of stem cell research. They are more frequently cited than any other stem cell type within the scientific literature, Google Trend data shows MSC searches to be approximately twice as common as the next most common adult stem cell type, and at least 1,753 MSC clinical trials have been pursued worldwide. There have also been an absolutely astounding 107,232 scientific articles published about MSCs to date. [Read more…]
From Feeder-free to Coating-free, DuoGenic StemCells corporation has developed the next generation hPSC culture medium: DuoESy.
1. Introduction: Regenerative Medicine in Taiwan
Taiwan is famous for its semiconductor, night markets and pearl milk tea. But few people know that the public health insurance, medical technique and cell therapy are also flourishing.
In 2018, Taiwan government partially lifted the regulation on cell therapy with a positive list according to the “Regulations of Special Medical Techniques”. The permitted cell types include autologous immune cell (NK, CIK etc.), chondrocyte, fibroblast, ADSC and BM-MSC for specific indications respectively. [Read more…]
Cynata Introduces Critical Innovation into MSC Manufacturing
In the context of cell therapy, product innovation is the introduction of a cellular product that is new or has significantly improved characteristics or intended uses. Over the past decade, a great deal of attention has been given to cell therapy product innovation, as demonstrated by the thousands of cell therapy products that have now entered clinical trials worldwide.
In contrast, process innovation refers to the implementation of a new or significantly improved production or delivery method. In the context of cell therapy, process innovation has received much less attention from the marketplace. [Read more…]
Mesenchymal Stem Cells (MSCs): Definitions, Nomenclature, and Terms
To analyze the emerging global market for mesenchymal stem cells (MSCs), it is important to define the cell type. Broadly defined, MSCs are multi-potent stem cells that can differentiate into a diverse range of cell types. More specifically, MSCs are non-hematopoietic stromal cells that are capable of differentiating into, and assisting in the repair of, tissues of both intra-mesenchymal and extra-mesenchymal lineages.
Interestingly, MSCs exert their therapeutic effects primarily through paracrine signaling, a process where they secrete bioactive molecules such as cytokines, growth factors, and extracellular vesicles to influence nearby cells and tissues, rather than through direct differentiation into the specific target cells they aim to support or repair.
In contrast, other stem cell types, like iPSCs, tend to have greater utility because of their differentiation potential.
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