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NeurExo Sciences to Host Teach-in Featuring Michael Chopp, PhD and Pioneering Exosome Technology

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— Research indicates exosomes have therapeutic potential for improving recovery after stroke, traumatic brain injury —

ATLANTA and DETROIT, January 23, 2019 – NeurExo Sciences, LLC (NXS), a biopharmaceutical company and subsidiary of NeuroTrauma Sciences, LLC, will be hosting a teach-in event featuring leading exosome researcher, Michael Chopp, Ph.D., Vice Chairman, Department of Neurology and Scientific Director, Neurosciences Institute, Zoltan J. Kovacs Chair of Neuroscience Research at Henry Ford Health System (HFHS), Detroit, and Distinguished Professor of Physics, Oakland University (MI).  Dr. Chopp’s presentation will provide a primer and overview of exosomes, small extracellular vesicles that provide a means of mediating intercellular communication.  He also will focus on his team’s pioneering technology employing exosomes engineered with enriched microRNA for the purpose of treating neurological disease and injury, including stroke and traumatic brain injury (TBI). [Read more…]

Stem Cell Medicine Licenses Exosome Technology for Treating Autism From Ramot at Tel Aviv University

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  • MSC-exo Technology Has Potential to Treat Autism Using Novel Intranasal Administration

  • Preclinical Studies Have Demonstrated a Benefit on Core Autism Symptoms

JERUSALEM, Jan. 2, 2019 — Stem Cell Medicine Ltd. (SCM), a biotechnology company developing new therapies for neurological indications, including mesenchymal stem cells and anti-BMP molecules for the treatment of Multiple Sclerosis, and gene therapy for the treatment of neuropathic pain, has licensed an innovative exosomes based technology for the treatment of neurodegenerative and neuropsychiatric indications, specifically, autism spectrum disorder (ASD). The treatment is based on vesicles, exosomes, derived from adult stem cells (MSC-exo) that are administered intranasally. The technology was developed by Professor Dani Offen, Sackler School of Medicine, Sagol School of Neurosciences Tel Aviv University and was licensed from Ramot, the Business Engagement Center at Tel Aviv University. [Read more…]

Top 4 Most Richly Funded Exosome Startups

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In recent months, exosome start-up companies have been the recipients of approximately $386.2 million in investor funding. Clearly, investors are feeling favorable toward companies developing exosome products and there is a growing belief that the industry is poised for growth.

Most Richly Funded Exosome Startups

To date, four companies have dominated the exosome funding world. These companies are:

  1. Codiak Biosciences
  2. Exosome Diagnostics
  3. Evox Therapeutics
  4. ExCoBio Inc.

[Read more…]

Exosome Companies | Tiny Exosomes, Enormous Potential

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Exosomes are small vesicles ranging from 30-100nm in size that are found in nearly all eukaryotic fluids and facilitate a range of important cellular functions. Although exosomes were discovered more than 30 years ago, it was not until recently that the scientific community began to give credit to exosomes for a range of promising traits.

In this article:

  1. What are Exosomes?
  2. Where are Exosomes Found?
  3. Exosome Therapeutics in Regenerative Medicine
  4. Exosome Market Momentum
  5. Companies Commercializing Exosome Technologies

Exosome Companies and Exosome Therapies

 

What are Exosomes?

Exosomes | Exosome Companies | Tiny Exosomes, Enormous Potential

Exosomes play an important role in various cellular functions. They transfer DNA, RNA, and proteins to other cells, thereby altering the function of the targeted cells.

Where are Exosomes Found?

Exosomes are commonly found in blood, urine, and saliva, among other fluids. Exosomes are also present in other body fluids, such as synovial fluid, amniotic fluid, semen, vaginal fluid, breast milk, and more.

Exosome Therapeutics in Regenerative Medicine

It has been long known that stem cells have the potential to exert therapeutic effects, but it has only been recently recognized that exosomes play an important role how stem cells exert their cellular functions.

Exosome Market Momentum

Recently, exosomes have been gaining momentum as a novel strategy for accessing the therapeutic effects of stem cells without the risks and difficulties of administering the cells to patients. Exosome companies are multiplying in number, with new market entrants popping up rapidly.

Interestingly, 25% of all exosome publications were released in the past year, which is providing new technologies to the marketplace for commercialization.

Companies Commercializing Exosome Technologies

Over the past few years, the following companies have emerged as specialists in exosome technologies. These exosome companies include:

  1. Aegle Therapeutics – Aegle is the first extracellular vesicle company to be cleared by the FDA to enter the clinical trials in humans. Aegle is using bone marrow- MSC derived extracellular vesicles to treat severe dermatological disorders.
  2. Anjarium Biosciences – Anjarium is developing a Hybridosome™ technology to engineer extracellular vesicles (including exosomes) to act as smart carriers. The technology allows therapeutic and diagnostic cargoes to be added into the lumen, as well as modification of vesicle surface properties (i.e. targeting ligands).
  3. Capricor Therapeutics – Capricor has an exclusive worldwide license agreement with Cedars-Sinai Medical Center for IP related to the development of exosomes originating from cardiosphere-derived cells (CDCs) for regenerative medicine applications.
  4. Codiak Biosciences – Codiak Biosciences’ technology capitalizes on the unique properties of exosomes which have been shown to deliver nucleic acids, proteins, lipids, and small molecules to various cell types.
  5. Creative Medical Technologies Holdings – The company has a patent application that covers the use of the company’s AmnioStem product as a production tool for the generation of exosomes to regenerate damaged brain tissue after a stroke.
  6. Exopharm – Exopharm is Melbourne-based start-up that has a patented purification technology called LEAP that can make proprietary exomeres in large scale and at low cost. Exomeres are pharmaceutical-grade vesicles sized 40-200nm that are purified using Exopharm’s LEAP ligand technology.
  7. Exosome Diagnostics – Exosome Diagnostics launched the first instrument for exosomal protein (exoProtein) capture and analysis directly from any biofluid.
  8. Evox Therapeutics – Evox Therapeutics is harnessing and engineering the natural trafficking capabilities of extracellular vesicles to develop an entirely novel class of biotherapeutics.
  9. Exosome Sciences – Exosome Sciences is working to discover exosome-based biomarkers to diagnose and monitor Alzheimer’s disease, Chronic Traumatic Encephalopathy (CTE), and other related conditions.
  10. Exosomics Siena SpA – Exosomics Siena SpA developed an exosome-based liquid biopsy that functions as a non-invasive cancer diagnostic.
  11. Exogenus Therapeutics – Exogenus Therapeutics (Exo-T) is a biotechnology company dedicated to pre-clinical and clinical development of exosome-based therapeutics for skin lesions.
  12. Kimera Labs – An FDA registered tissue facility, Kimera Labs is developing amniotic treatments and pharmaceutical grade, exosome-based regenerative therapies.
  13. Lonza – Lonza announced May 2017 that it had acquired HansaBioMed Life Sciences, a supplier of technology and services for exosome research, and also invested in Exosomics, an Italian firm developing next-generation sequencing-based cancer tests.
  14. ReNeuron – ReNeuron is a clinical stage biotechnology company headquartered in the UK that is developing exosomes derived from its CTX neural stem cell line.
  15. RoosterBio – RoosterBio and Exopharm announced August 2017 that they will collaborate on a Stem Cell Exomere Program, aimed to bring high-grade therapeutic extracellular vesicles/exosomes derived from adult stem cells into clinical practice.

Want to learn about this rapidly growing area? View “The Market for Stem Cell Exosomes.”Exosome Market Analysis | Exosome Companies | Tiny Exosomes, Enormous Potential

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As the first and only market research firm to specialize in the stem cell industry, BioInformant research is cited by The Wall Street Journal, Xconomy, AABB, and Vogue Magazine. 

Know of other exosome companies that should be on this list? Add them in the comments below.

Up Next: Current Snapshot of the Exosome Market

Exosome Research: Who Is Dominating in the Scientific Literature?

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Exosome research is on the rise, fueled by an increasing recognition of the central role that exosomes play in intercellular (cell-to-cell) communication and transportation. As intracellular messengers, exosomes have the potential to mediate many of the therapeutics effects commonly associated with cells, with far fewer risks.

In this article:

  1. Exosome Research by Dr. Gabrielsson
  2. Unicyte AG on Exosomes Therapy
  3. Leading Exosome Research Journals

Exosome Research

 
For competitors within the exosome marketplace, it is vital to assess existing and future trends. One of the best tools for assessing scientific progress is to review rates of exosome research.

When exosome publications are analyzed, U.S. authors have published approximately 40% of the articles and Chinese authors take second place.[1]

When the term “exosome” is searched within scientific literature, Dr. Susanne Gabrielsson from the Karolinska Institutet in Sweden is the leading author, with 37 articles, making her one of the global authorities on exosome research.

Exosome Research by Dr. Gabrielsson

Karolinska Institutet | Exosome Research: Who Is Dominating in the Scientific Literature?

A full list of Dr. Gabrielsson’s exosome publications can be viewed at this link:

https://www.ncbi.nlm.nih.gov/pubmed/?term=Gabrielsson+S%5BAuthor%5D+AND+exosome

Unicyte AG on Exosomes Therapy

Unicyte AG on Exosomes Therapy | Exosome Research: Who Is Dominating in the Scientific Literature?

When the term “extracellular vesicles” is searched, Unicyte AG, a regenerative medicine unit of Fresenius Medical Care, takes the lead. Headquartered in Switzerland, the company has published more than 100 papers on exosomes and extracellular vesicles in combination with Prof. Giovanni Camussi. The company is also a market leader in terms of patents and translational programs.

Leading Exosome Research Journals

Interestingly, two scientific journals have been particularly favorable toward exosome publications, publishing the greatest quantity to date:

PLOS ONE | Exosome Research: Who Is Dominating in the Scientific Literature?

JBC | Exosome Research: Who Is Dominating in the Scientific Literature?

Google Trend data also shows a clear linear increase in interest in exosome-related topics. To compete for dominance within this market, it is essential to identify trends as they begin to impact the marketplace, not after they are in full effect.

To learn more, view the “Market for Stem Cell Exosomes.”

Market for Stem Cell Exosomes | Exosome Research: Who Is Dominating in the Scientific Literature?

If you found this blog valuable, subscribe to BioInformant’s stem cell industry updates.

As the first and only market research firm to specialize in the stem cell industry, BioInformant research is cited by The Wall Street Journal, Xconomy, AABB, and Vogue Magazine. Bringing you breaking news on an ongoing basis, we encourage you to join more than half a million loyal readers, including physicians, scientists, executives, and investors.

In your opinion how will the research into exosome characterization advance regenerative medicine? Share your thoughts in the comments section below.

Up Next: Explosion of Interest In Exosome Technologies And Companies Leading The Charge

 

Footnotes
[1] Search on PubMed.gov. Search Term: “exosome” or “exosomes”. Date of Search: December 1, 2017.
[2] Ncbi.nlm.nih.gov. (2017). “PLoS ONE” AND exosome – PubMed – NCBI. [online] Available at: https://www.ncbi.nlm.nih.gov/pubmed/?term=%22PLoS+ONE%22+AND+exosome [Accessed 12 Nov. 2017].
[3] Ncbi.nlm.nih.gov. (2017). “J Biol Chem” AND exosome – PubMed – NCBI. [online] Available at: https://www.ncbi.nlm.nih.gov/pubmed/?term=%22J+Biol+Chem%22+AND+exosome [Accessed 12 Nov. 2017].\

 

Editor’s Note: This post was originally published on October 11, 2018, and has been updated for quality and relevancy.

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