MSCs have many fascinating properties, including strong immunomodulatory effects, the ability to repair damaged tissues, and the capacity in vitro to differentiate into other cells types. These traits, combined with their easy availability from different sources, has prompted researchers to look at MSCs as promising raw materials for use in cell therapy, gene therapy, and tissue engineering, the three pillars of regenerative medicine. The cumulative efforts of scientists, researchers and life science companies have resulted in the development of 10 MSC-based approved therapeutics and 19 MSC-based approved bone matrices. [Read more…]
Mesenchymal Stem Cells (MSCs)
Mesenchymal stem cells (MSCs) are a well-characterized population of adult stem cells that can differentiate into a variety of cell types (chondrocytes, osteoblasts, adipocytes, myocytes, and more).
MSCs as Essential Raw Materials for Regenerative Medicine Products
MSCs are essential raw materials for many regenerative medicine products, including cell-based therapies, engineered tissues, cosmeceutical preparations, exosome products, and cultured meat. As of August 27, 2023, ClinicalTrials.gov lists at least 1,457 registered clinical trials involving MSCs, targeting a variety of indications ranging from graft vs. host disease (GvHD) to macular degeneration to osteoarthritis. Although ten MSC-based therapeutics have been approved for marketing in other parts of the world, the U.S. FDA is yet to approve an MSC product. Nonetheless, given their therapeutic potential for treating many indications and usage across a variety of applications, researchers believe that MSCs will support many important regenerative medicine advances. [Read more…]
MSC-Derived Therapeutics and Exosomes as Rising Stars in Advanced Therapeutics
Today, the term MSC describes a class of cells that have historically been known as mesenchymal stem cells, mesenchymal stromal cells, and medicinal signaling cells, among other names. The clinical utility of MSCs is primarily attributed to their key biological properties, which include: [Read more…]
Could MSC Therapeutics Revolutionize Modern Medicine as We Know It?
MCSs are multipotent progenitor cells capable of developing into a variety of cell types during human development, including adipocytes, chondrocytes, osteocytes, and cardiomyocytes. Population aging and an increasing prevalence of chronic disease are driving interest in MSC-based therapies. Over the past 150 years, the average human lifespan has doubled and continued increases in life-expectancy are expected. [Read more…]
New Study Reveals Breakthrough in Epidermal Regeneration Using Mesenchymal Stem Cell Extracellular Vesicles and Ronawk’s Bio-Blocks™
Overland Park, KS – In a groundbreaking development, a recent peer-reviewed paper titled “Mesenchymal Stem Cell Extracellular Vesicles from Tissue-Mimetic System Enhance Epidermal Regeneration via Formation of Migratory Cell Sheets,” published on July 29, 2023, in the journal “Tissue Engineering and Regenerative Medicine,” offers open access to its findings. [Read more…]
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