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Stem Cells in Drug Discovery: A Changing Paradigm

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Drug discovery involves high cost and uncertain outcomes.  Only a few companies can take the risk of investing enormous amounts of money into research and testing, only to see undesirable side effects emerging during the final human clinical trials. In many cases, companies are spending millions of dollars to fail during clinical testing.

Now, some new medicines are being tested for safety on specialized cells developed from human pluripotent cell lines. Cells types which are frequently being using within drug discovery applications include heart (cardiomyocytes) and liver cells (hepatocytes), which are the organs where 80% of drug failures occur. [Read more…]

Who Discovered Stem Cells? The Answers Revealed

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Who discovered stem cells is a question worthy of exploration. While Robert Hooke first discovered the concept of cells themselves, the discovery of stem cells is usually credited to Drs. James Till & Ernset McCulloch.

For several hundred years, researchers have known that the human body is comprised of trillions of tiny structures. Known as cells, these structures can only be seen at a microscopic level. These cells come in hundreds of variations – 200, to be exact – and serve multitudinous functions within the human body.

These functions include pumping blood, digesting food, and ridding our bodies of toxins and waste products, among others.

In this article:

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How Mesenchymal Stem Cells Could Revolutionize Modern Medicine

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Mesenchymal stem cells (MSCs) are multipotent progenitor cells capable of developing into a variety of cell types, such as adipocytes, chondrocytes, osteocytes, and cardiomyocytes. Population aging and an increasing prevalence of chronic disease are driving interest in MSC-based therapies.

Over the past 150 years, the average human lifespan has doubled and continued increases in life-expectancy are expected.

In China, the country expects to have half a billion people over the age 60 by 2050. In Japan, the government expects to have 50% of the population over 65 within two decades. Similar demographics are affecting Europe and the United States, all of which are accelerating the market opportunities for cell-based therapeutics, such as MSCs. [Read more…]

BMS Pays Evotec $6M as Companies Expand iPSC Collaboration

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Adding Cell Types Supports Drug Discovery of Disease-Modifying Therapies for Neurodegenerative Diseases and Triggues U.S. $6 M Payment to Evotec 

Hamburg, Germany, January 7, 2020 – Evotec SE (Frankfurt Stock Exchange: EVT, MDAX/TecDAX, ISIN: DE0005664809) announced today that the Company received a US$ 6 m payment from Bristol-Myers Squibb Company (NYSE:BMY) following the decision to expand the collaboration to include additional cell lines.

Evotec and Celgene, which is now a Bristol-Myers Squibb company, initiated the collaboration in December 2016 to identify disease-modifying treatments for a broad range of neurodegenerative diseases. Currently approved drugs only offer short-term management of patients’ symptoms and there is a huge unmet medical need for therapies that slow down or reverse disease progression in the field of neurodegenerative diseases.

This collaboration pursues an innovative approach to the discovery and development of novel medicines by leveraging several of Evotec’s unique technology platforms in conjunction with the human iPSC based platform, which is one of the largest and most sophisticated platforms in the industry. The iPSC partnership between Bristol-Myers Squibb and Evotec has already been expanded with additional cell lines several times. [Read more…]

International Perinatal Stem Cell Society to Host Two Scientific Conferences in 2020

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Kyle Cetrulo, President
Kyle Cetrulo, President, International Perinatal Stem Cell Society

The International Perinatal Stem Cell Society is a non-profit organization founded on the principle that stem cells from perinatal tissues contain enormous, untapped potential to treat many diseases and disorders worldwide.

For many years, the Perinatal Stem Cell Society has been hosting an annual conference featuring the world’s leading perinatal stem cell researchers, specializing in Amnion, Amniotic Fluid, Cord Blood for Regenerative Medicine, Cord Tissue, and the Placenta. Its scientific programs cover all aspects of the perinatal stem cell field, with opportunities to learn from leading clinicians utilizing cellular therapies within their practices.

Below, Kyle Cetrulo, President of the International Perinatal Stem Cell Society, explains the future of perinatal stem cell science and the role that the Society’s 2020 Scientific Conferences will play in advancing this mission. [Read more…]

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