Exosomes have recently exploded in popularity, with companies developing exosome-based diagnostics, therapeutics, and cosmeceuticals. Although they were discovered more than 30 years ago, it was not until recently that the scientific community began to give credit to exosomes for a range of promising traits. [Read more…]
Mesenchymal Stem Cells (MSCs)
Mesenchymal stem cells (MSCs) are a well-characterized population of adult stem cells that can differentiate into a variety of cell types (chondrocytes, osteoblasts, adipocytes, myocytes, and more).
Key Dates in the Discovery of Mesenchymal Stem Cells (MSCs)
Mesenchymal stem cells (MSCs) have inspired a great deal of activity as a novel therapeutic approach. Presently, MSC-based clinical trials are being conducted for a variety of disease conditions, with an increasing number of trials demonstrating safety and efficacy.
Clinical utility of MSCs can be attributed to four key biological properties:
- Their potential to migrate to sites of inflammation caused by tissue injury when injected intravenously
- Their potential to differentiate into different cell types
- Their potential to release different bioactive molecules that can stimulate the recovery of injured cells
- Their ability to modulate inflammation and accomplish immunomodulatory functions
Currently, over 1,670 MSC clinical trials are in progress across different parts of the world. The majority of these studies are using adipose-derived MSCs and bone marrow-derived MSCs. Nearly 75% (three-quarters) of these clinical studies are using MSCs for the development of regenerative medicine products. Approximately 14% of the studies are using MSCs for disease modeling. The remaining 11% of the studies are using MSCs for drug discovery and cytotoxicity testing applications.
Today, 12 MSC-based therapies have been approved globally. The Republic of Korea has approved five products: Queencell from Anterogen, Cellgram AMI from Pharmicell, Cupistem from Anterogen, Cartistem from Medipost, and NeuroNataR from Corestem. Japan has approved two products: Temcell HS from JCR Pharmaceuticals and Stemirac from Nipro Corporation. India has approved one product: Stempeucel from Stempeutics. Iran has approved MesestroCell developed by Cell Tech Pharmed. EMA in Europe has approved two products: Holoclar from Chiesi Farmaceutici and Alofisel from TiGenix/Takeda. Australia has approved Remestemcel-L from Mesoblast.
Despite this progress, no MSC-based therapeutic have yet received U.S. FDA approval, although the FDA is actively reviewing Mesoblast’s Remestemcel-L.
One of the major bottlenecks to the industry is how to manufacture clinical-grade MSCs on a commercial scale, which Australian regenerative medicine company Cynata Therapeutics (ASX:CYP) is aiming to solve. Cynata Therapeutics is pioneering iPSC-derived MSC production technologies, enabling large-scale therapeutic development. At present, there are at least eight companies who are involved with the development of iPSC-derived MSCs therapeutics (iMSCs), including Cynata Therapeutics, Eterna Therapeutics, Implant Therapeutics, Bone Therapeutics, Brooklyn ImmunoTherapeutics, Fujifilm CDI, Citius Pharmaceuticals, and Kiji Therapeutics.
To fully understand the cell type and its evolution over time, this post considers key dates in the discovery of mesenchymal stem cells (MSCs). [Read more…]
Do Stem Cell Treatments For Arthritis Work?
Can stem cell treatments for arthritis bring relief to those suffering from the disease? For all of human time, the swelling and aching of joints has been a common experience. As connective tissue breaks down over time, the result is stiffening, pain, and immobility. The three most common causes of arthritis include joint injuries, age-related wear and tear, and autoimmune disorders. While some people are luckier than others, few people seem to escape it entirely, which is why stem cell treatments for arthritis are intriguing to so many.
Today, the most common kinds of arthritis are osteoarthritis (OA), rheumatoid arthritis (RA), and psoriatic arthritis (PA).
Because BioInformant is a publisher of stem cell industry news, we understandably don’t offer stem cell treatments. However, our Founder is a stem cell patient, and as a company of analysts, we do our best to track this evolving industry. With this context, let’s dive into how stem cells are currently being utilized for the treatment of arthritis in novel and intriguing ways.
Top 5 TED Talks About Stem Cells
Check out the best TED Talks below to understand the growing importance of stem cells within regenerative medicine.
In this article:
Stem Cell Fillings Replace The Need For Root Canal Procedure
Those who live in fear of the infamous root canal – maligned worldwide for its painful nature and disliked for the fact that it kills the tooth – will find relief in the news that researchers have found a promising alternative in the form of stem cell fillings. This approach relies on treating root causes and conditions (no pun intended) rather than treating surface symptoms. The goal of regenerative medicine? To return former functionality to the body – in this case, the tooth.
The goal behind stem cell fillings is to repair the tooth as though the damage had never occurred. Of course, this approach raises many questions. How is it different than a root canal? Where do you get the stem cells? Are there risks involved? The goal of this article is to answer these questions. [Read more…]
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