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Home » Orig3n

ORIG3N, Producing Patient-Specific iPS Cells – Interview with Robin Smith, CEO

November 12, 2018 By Cade Hildreth (CEO) Leave a Comment

ORIG3N

ORIG3N ORIG3N, a biotechnology start-up headquartered in Boston, is attracting global attention for several reasons. First, it has created the world’s largest blood cell repository. ORIG3N is using these blood cells to produce patient-specific induced pluripotent stem cells (iPSCs), allowing the cells to be ever-renewing and giving rise to a living database of humanity known as LifeCapsule.

Second, the company has two other business segments, called LifeProfile and LifeSystems. These business units of ORIG3N help people to better understand the links between their genes and how their minds and bodies work.

Third, ORIG3N has identified HLA Superdonor matches for 90% of the U.S. population, positioning it to be custodians of this “first of a kind asset on planet earth.”

[Read more…]

Filed Under: Interviews, iPS Cells Tagged With: genetic testing, interview, iPSC, news, Orig3n

Using HLA “Super Donors”, ORIG3N’s Crowdsourced Cell Repository Contains Donor Matches for 90% of U.S.

November 27, 2016 By Cade Hildreth (CEO) Leave a Comment

ORIG3N HLA superdonors

ORIG3N Inc.ORIG3N announced it has identified “super donor” matches for 90 percent of the U.S. population. The discovery will accelerate how quickly and successfully we match people for transplants, as tissue can be generated from these cells. ORIG3N was able to achieve this milestone approximately 5x faster than its Japanese counter parts because it has built the world’s largest crowdsourced cell repository called LifeCapsule.

HLA is short for “human leukocyte antigen.” It is a gene complex encoding the cell-surface proteins that control regulation of the human immune system. More simply, it is a protein found on most cells of your body that determines how your body recognizes what is you versus other.

HLA “super donors” are people with tissues that are immunologically compatible with a large percentage of the human population. They are very rare in the population, making them difficult to identify.ORIG3N - HLA Super Donor

The signficanceof this announcement by ORIG3N is that for the first time in history, a complete set of matched samples has been identified and can be industrially produced. Utilizing induced pluripotent stem cell (iPSC) technology, any of the 200+ tissues that compose the human body can now be created.

Importantly, these tissues would be an exact match to the individuals requiring them, even though they were derived from another person (an allogenic transplant).

According to ORIG3N, in the near future, this approach may allow people to rapidly get an exact match for a transplant, instead of waiting for months. Instead, tissues could be “pre-produced.”

For more information, visit www.orig3n.com.

Filed Under: iPS Cells, Stem Cell News Tagged With: HLA, Orig3n, super donors

ORIG3N Executes DNA Testing on Nearly 450 XMed Attendees in Under 48 Hours

October 12, 2016 By Cade Hildreth (CEO) Leave a Comment

ORIG3N DNA Testing

ORIG3N DNA TestingOne biotech company put the mission of this week’s Exponential Medicine Conference to work by proving that is is possible to deliver real-time, accurate DNA testing. Exponential Medicine is a unique four-day conference that gathers world-class faculty, innovators and entrepreneurs from across the biomedical and technology spectrum to “explore the convergence of fast moving technologies.” [Read more…]

Filed Under: iPS Cells, Press Releases, Stem Cell News Tagged With: genetic testing, LifeCapsule, Orig3n

ORIG3N and Kangstem Biotech Partner to Investigate Induced Neural Stem Cells for Disease Modeling

June 22, 2016 By Cade Hildreth (CEO) Leave a Comment

ORIG3N and Kangstem Biotech Collaborating to Use Induced Neural Stem Cells for Disease Modeling

Boston biotech company ORIG3N has announced a collaboration with South Korea’s Kangstem Biotech in a joint effort to gain insight on the effectiveness of induced neural stem cells (iNSC) in disease modeling. As a pioneer of regenerative medicine, ORIG3N is leading the way towards the future of medicine by crowdsourcing blood samples to create the world’s largest and most diverse biorepository of stem cells.

As part of this collaboration, Kangstem Biotech will be providing iNSC’s to ORIG3N for research. This partnership between a pioneer in the biotechnology industry and one of the largest global biopharmaceutical companies is an exciting development in regenerative medicine. [Read more…]

Filed Under: iPS Cells, Neural Stem Cells Tagged With: iPSC, Kang Stem Biotech, neural stem cells, Orig3n

ORIG3N Opens Laboratory and Expanded Headquarters to Support World’s Largest Crowdsourced Biorepository of iPSCs

April 26, 2016 By Cade Hildreth (CEO) Leave a Comment

ORIG3N Opens Regenerative Medicine Laboratory and Expanded Headquarters In Boston's Innovation District - ORIG3N-MayorVisit-CraigCarpenter06

In major news released today, ORIG3N announced that it has opened a new regenerative medicine laboratory and expanded headquarters in Boston.

Founded in 2014, ORIG3N is creating the world’s largest crowdsourced biorepository of induced pluripotent stem cells (iPSCs) called LifeCapsule™. It uses these blood cells to produce patient-specific iPSCs to grow different cell types, including heart cells (cardiomyocytes), liver cells (hepatocytes), brain cells (neurons), and more.

In addition to collecting donated blood samples for iPSC production, ORIG3N offers an optional LifeCapsule membership, in which individuals can pay $99/year to get permanent access to their own immortalized iPS cells. ORIG3N also has two other business units, LifeProfile and LifeSystems, which are discussed in detail in the interview below.

Learn more by reading the full press release below, printed with permission from Julie Hall, Managing Director of Havas Health and media contact for ORIG3N. [Read more…]

Filed Under: iPS Cells, Stem Cells Tagged With: iPSC, LifeCapsule, Orig3n, regenerative medicine, Robin Smith

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