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Direct Cell Reprogramming: What Is It and How Does It Work?

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There has been tremendous activity over the last decade in the development of stem cells therapeutics, which have relied on stem cell differentiation protocols, as well as techniques for direct cell reprogramming. Today, there are over 6,880 stem cell trials registered on ClinicalTrials.gov and publications have increased dramatically in recent years, demonstrating the rapidly growing interest of the scientific community.

However, for all their promise, stem cells are yet to deliver on this therapeutic potential, and this failure appears due to various technical challenges that still need to be overcome. [Read more…]

4 Major Areas of Commercialization for iPS Cells

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Since the discovery of induced pluripotent stem cells in 2006, a great deal of basic research has been done to understand how to produce, manipulate, and utilize the stem cell type.  In addition to this important basic research, a great deal of applied (“translational”) results has been done with the cell type. Induced pluripotent stem cells (also called iPS cells or iPSCs) are revolutionizing regenerative medicine because they represent a potential route for producing patient-specific stem cells for research or clinical use.

In the future, iPS cells will facilitate progress in personalized medicine by allowing a patient to use his or her own cells. In addition, iPSCs also show great promise in other areas, such as phamaco-toxicological screening, by allowing disease modeling and safety assessment of potential new drugs under development, in short, facilitating the study of a “disease in a dish.”

[Read more…]

Custom iPSC Engineering Services – 4 Reasons to Choose Applied StemCell

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Applied StemCell Inc. (ASC) is a gene-editing company that offers an optimized series of tools for basic research study, drug discovery, bio-processing, bio-production and preclinical applications. Currently, the company is focused on the following areas:

  1. Cell line generation for bio-production and bioassays
  2. Patient-relevant cell models for personalized medicine
  3. Physiologically predictive animal and cellular models of human disease

Applied StemCell uses its TARGATT™ technology to specifically insert a gene-of-interest at a well-characterized, transcriptionally active locus in the genome with guaranteed transgene expression. This site-specific knock-in technology was first established in mouse models, and ASC has successfully applied it to human cell lines.

ASC has leveraged this technology across various projects that combine the complementary CRISPR/Cas9 technology and TARGATT™ for highly specified transgene expression. [Read more…]

Human Induced Pluripotent Stem Cell (iPSC) Derived Tissues – Present & Future Outlook

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In this article, the present and future outlook for human iPSC derived tissues is explored. Induced pluripotent stem cells (iPSCs) are differentiated cells that are reprogrammed into a pluripotent state, allowing a wide range of cell and tissue types to be derived from them.

Key findings include:

  • iPSC technology is moving from a boutique phenomenon to industrialized cellular models.
  • Increasing recognition by industry and regulatory bodies for detecting a variety of toxicities.
  • Emerging utility for predicting cardio and neuro-related oncology adverse effects.

[Read more…]

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