Stem Cell News

Axol Bioscience has been awarded a SMART Grant by Scottish Enterprise to Accelerate ALS Research through the development of ALS-related phenotypes using human iPSCs. This represents another significant step towards better disease modelling and ALS drug discovery.

The key objectives of this project are to:

1. Develop a quality manufacturing system for iPSC-derived ALS relevant cell types
2. Characterise and validate the cells using ALS relevant end points; TDP43 aggregation, Neurofilament Light elevation and Cryptic Exon Sequencing
3. Develop and characterise an ALS co-culture model which includes motor neurons, microglia and astrocytes
4. Commercialise an easy-to-use model system to drive forward ALS drug discovery

[Read more…]

Unprecedented resource, created with Cedars-Sinai, to accelerate ALS research and drive development of targeted therapies globally

NEW ORLEANS –In a landmark continuing collaboration, Answer ALS and Cedars-Sinai have announced the completed availability of the largest amyotrophic lateral sclerosis (ALS) patient-based induced pluripotent stem cell (iPSC) and bio data repository. The repository encompasses biological and clinical data from nearly 1,000 ALS patients, offering an unprecedented resource for global researchers studying ALS, commonly known as Lou Gehrig’s disease. [Read more…]