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Exosomes, a Rising Star in Regenerative Medicine (Company Spotlights)

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Exosomes are small vesicles ranging from 30-100nm in size that are found in nearly all eukaryotic fluids and facilitate a range of important cellular functions. They transfer DNA, RNA, and proteins to other cells, thereby altering the function of the targeted cells.

In recent years, exosomes have gained attention as a strategy for accessing the therapeutic effects of cells without the risks and difficulties of administering the cells to patients. With at least 12,431 scientific articles published about exosomes and 128 clinical trials underway, these small vesicles have intriguing potential to be used within a range of therapeutic applications. [Read more…]

First Dosing in Plexoval Exosome Wound Healing Human Study

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Highlights

  • First human dosing of Plexaris™ has occurred in Exopharm’s PLEXOVAL Study
  • PLEXOVAL is a world-first study using a cell free, platelet-derived exosome product manufactured using Exopharm’s proprietary LEAP Technology for wound healing
  • Other pre-clinical development progress will be reported over coming months

MELBOURNE, Australia – Jan. 29, 2020 11:00 UTC — Regenerative medicine company Exopharm Limited (ASX:EX1) announces first dosing has occurred in the PLEXOVAL Phase I study using exosomes isolated from human platelets for wound healing, Exopharm’s first human clinical trial. Further participants are expected to soon follow in this study that involves up to 20 participants. [Read more…]

Another Exosome Company Has Sprouted Up: Regen Suppliers (ReBellaXO)

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With exosome companies rapidly populating in recent years, some of the companies have been working closely with the U.S. FDA to get a specific IND for each clinical condition. Other exosome companies have not and have been supplying their exosome products to consumers without regulatory oversight, despite the FDA being very clear that exosomes are now under their purview.  

On January 16, 2020,  yet another exosome company entered the public eye. The latest supplier of exosome products is Regen Suppliers, based in Scottsdale, Arizona. [Read more…]

Aegle Therapeutics Raises $4M to Fund First Trial in the U.S. Using Exosomes from Allogeneic MSCs

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Aegle Therapeutics raises $4 million to fund a groundbreaking stem cell exosome clinical trial to treat the orphan disease, Dystrophic Epidermolysis Bullosa.

BOSTON and MIAMI, Jan. 7, 2020 — Aegle Therapeutics Corp., a first in class biotechnology company isolating extracellular vesicles, including exosomes (“EVs”), secreted by mesenchymal stem cells as therapy, announced the closing of a $4M financing. Aegle’s platform technology is initially being developed to treat dystrophic epidermolysis bullosa (“DEB”), a rare pediatric skin blistering disorder.  [Read more…]

PLEXOVAL Exosome Wound Healing Human Study Starts

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  • A world-first study using cell free exosome product manufactured using Exopharm’s LEAP Technology

  • Study sites at the Royal Melbourne Hospital and Australian Red Cross Blood Service

  • Results by mid 2020

26 August 2019, Melbourne, Australia: Regenerative medicine company Exopharm Limited (ASX:EX1) announces the start of the PLEXOVAL Phase 1 study, the first human clinical trial using exosomes for wound healing. [Read more…]

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