Without a doubt, stem cell manufacturing plays a critical role within the rapidly expanding stem cell sector. Progressing a cell-based therapeutic from pre-clinical stage production through later clinical stages and into commercial production requires scale-up. Historically, the production of adequate quantities of stem cell based therapeutics has been a major challenge and bottleneck for the industry. Thankfully, a growing number of technologies are now being adopted to support the production of emerging cell therapies. [Read more…]
In 1938, American doctor Dorothy Anderson noted a condition in which individuals suffered damage to the pancreas, calling it cystic fibrosis. Other physicians of her time and even earlier noted symptoms such as salty skin and thickened mucus, making it hard to breathe and function normally. While in recent decades, scientists have gained a much better understanding of what cystic fibrosis does to the body, they haven’t had nearly as much luck in finding an effective course of cystic fibrosis treatment. Luckily, that may soon change. [Read more…]
Investigational New Drug (IND) Using RoosterBio’s CliniControl™ Products Enters the Clinic by RoosterBio’s Pharmaceutical Customer
RoosterBio Inc., a leading supplier of human mesenchymal stem/stromal cell (hMSC) working cell banks and hMSC bioprocess systems, announces today a significant milestone in the regenerative medicine field with the dosing of the first patient using its innovative cellular starting materials. The patient has been treated by RoosterBio’s pharmaceutical customer with an Investigational New Drug (IND) that was manufactured using RoosterBio’s CliniControl cell and media systems. [Read more…]
Stem cells are primitive cells that are characterized by self-renewal and the capacity to differentiate into mature cell types. Scientists believe they may have the potential to cure diseases and improve the quality of life for many.
Uses of stem cells are rapidly expanding. Potential applications range from the use of stem cells in reversal and treatment of disease, to cell therapy, tissue regeneration, bioprinting, drug discovery, toxicology testing, clean meat production and more. [Read more…]
When learning about stem cells, a common question is, what is the difference between totipotent, pluripotent, and multipotent cells? The answer is simple.
The key differences between these cells are:
- When each appears during the process of human development.
- Their degree of “flexibility” to become other cell types.
The key similarity is that all three of these cells types are characterized by self-renewal and the capacity to turn into into mature cell types. Together, they form the 200+ cell types that create a human being.
Let’s dive deeper into these differences below.
Totipotent Stem Cells
Totipotent stem cells are the most versatile stem cell type, because they are formed shortly after fertilization of an egg cell by a sperm cell. They can become all of the cells of the human body, as well as the cells of the embryo and developing fetus.
At about four days into development, these totipotent cells specialize slightly, becoming pluripotent stem cells. [Read more…]