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RYONCIL (remestemcel-L) is the first MSC product approved by FDA for any indication.
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In a single-arm, multi-center, Phase 3 trial of children with steroids-refractory (SR) acute GvHD, 70% achieved an overall response by Day 28 of treatment with RYONCIL, a measure that predicts survival.
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RYONCIL’S immunomodulatory effects, including inhibition of T cell activation and secretion of pro-inflammatory cytokines, position the therapy for potential other indications in diseases with excessive inflammation.
Mesenchymal Stem Cells (MSCs)
Mesenchymal stem cells (MSCs) are a well-characterized population of adult stem cells that can differentiate into a variety of cell types (chondrocytes, osteoblasts, adipocytes, myocytes, and more).
How 3D Printing with Stem Cells will Alter the Future of Medicine
Without question, 3D printing is one of the most transformative technologies of the 21st century, impacting diverse fields that include medicine, science, technology, manufacturing, military defense, and more. Among its exciting and varied applications, combining 3D printing technologies with stem cells is one of the most exciting.
For this reason, this article explores critical advances in 3D printing and how this technology is creating positive opportunities for stem cell companies and investors.
New Study Reveals Breakthrough in Epidermal Regeneration Using Mesenchymal Stem Cell Extracellular Vesicles and Ronawk’s Bio-Blocks™
Overland Park, KS – In a groundbreaking development, a recent peer-reviewed paper titled “Mesenchymal Stem Cell Extracellular Vesicles from Tissue-Mimetic System Enhance Epidermal Regeneration via Formation of Migratory Cell Sheets,” published on July 29, 2023, in the journal “Tissue Engineering and Regenerative Medicine,” offers open access to its findings. [Read more…]
Revolutionary Study Introduces Advanced Approach to Epidermal Regeneration Using Mesenchymal Stem Cell Secretome and Ronawk’s Bio-Blocks™
Overland Park, KS – A groundbreaking study titled “Tailoring the Secretome Composition of Mesenchymal Stem Cells to Augment Specific Functions of Epidermal Regeneration: An In Vitro Diabetic Model,” conducted by, Jacob G. Hodge, Ph.D., introduces a pioneering strategy to revolutionize epidermal regeneration using the secretome of mesenchymal stem cells (MSCs) utilizing Ronawk’s Bio-Blocks™. Published in June 2023 in the journal
“Frontiers in Medical Technology” and available through open access, the study unveils a powerful solution for optimizing wound healing, particularly in a diabetic context. [Read more…]
Dr. Chris Centeno, Visionary Behind Regenexx® Stem Cell Technology
Dr. Chris Centeno is an international expert in regenerative medicine and the clinical use of mesenchymal stem cells (MSCs) for orthopedic applications. This is Part 2 of an interview with Dr. Centeno.
Read Part 1 of the interview here.
ACL Surgeries and Regenexx Stem Cell Technology
Dr. Centeno specializes in clinical use of adult stem cells for orthopedic injuries, which he treats through same-day procedures at his clinic in Denver, Colorado, and through cultured expansion of mesenchymal stem cells at a clinic in Grand Cayman. He first performed these adult stem cell procedures in the U.S. in 2005-2006, and his clinic has since has treated thousands orthopedic patients with stem cell based therapies.
Dr. Chris Centeno is best known for the Regenexx® technology, an approach that uses needle-based procedures coupled with sophisticated guidance techniques to place large numbers of stem cells at the site needing repair. This approach can often replace the need for invasive orthopedic surgeries. [Read more…]
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