Despite decades of investigation, stem cell therapies are still facing challenges around their commercialization. The stem cell therapy market has been struggling to achieve approvals and high price tags have made it difficult to generate sales for those that do reach commercialization. Moreover, it is a challenging task to introduce foreign living cells into a system as complex as the human body. [Read more…]

Exosomes are produced and secreted out by nearly all living cells and have been found to occur in nearly every bodily fluid. They are found abundantly in the growth medium of many cultured cells, such as B lymphocytes, dendritic cells, cytotoxic T cells, intestinal epithelial cells, neurons, oligodendrocytes, platelets, mast cells and Schwann cells. [Read more…]

Naïve exosomes can be engineered to load drugs into their lumen using two different technologies: passive drug loading and active drug loading. These “drugs” can include RNAs, proteins, and nucleic acids, as well as other payloads. Today, a growing number of companies are using engineered exosomes for therapeutic purposes and studies by these companies have confirmed that exosomes can effectively serve as carrier vehicles for several types of bioactive molecules. Several exosome therapeutics have also entered into clinical testing. [Read more…]