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Home » Cell Therapy » CAR-T » Page 3

Luminary Therapeutics and Case Western Reserve University Enter Formal Collaboration for Development of BAFF CAR

July 7, 2020 By Cade Hildreth (CEO)

Luminary Theraptuics and Case Western Reserve - BAFF CAR

Luminary Tx and CWRU enter formal collaboration for clinical development of novel BAFF CAR to treat Mantle Cell Lymphoma and Sjogren’s Syndrome

MINNEAPOLIS, MN, USA, July 7, 2020– Luminary Therapeutics (Luminary Tx) and Case Western Reserve University have entered into a formal collaboration agreement that includes an option for Luminary to exclusively license a novel BAFF target for use in CAR-T (chimeric antigen receptor T cells) constructs. [Read more…]

Filed Under: CAR-T, Cell Therapy, Press Releases, Stem Cell News Tagged With: CAR-T

Novartis’ Kymriah® Wins Latest FDA RMAT (42 Announced)

April 22, 2020 By Cade Hildreth (CEO)

Kymriah RMAT

Novartis Kymriah® receives FDA Regenerative Medicine Advanced Therapy designation in follicular lymphoma.

  • If approved, relapsed or refractory (r/r) follicular lymphoma would become the third B-cell malignancy indication for Kymriah, joining approvals in children and young adults with r/r ALL, and adults with r/r DLBCL
  • The Regenerative Medicine Advanced Therapy (RMAT) designation reflects the unmet need for patients with r/r follicular lymphoma
  • US regulatory filing for Kymriah in r/r follicular lymphoma anticipated in 2021

[Read more…]

Filed Under: CAR-T Tagged With: RMAT

History of CAR-T Cell Therapy Spans 60+ Years

March 13, 2020 By Cade Hildreth (CEO)

history of car-t cell

The groundbreaking approvals of two CAR-T therapies in 2017 was the climax of more than sixty years of devoted research. In the 1950s, the discovery of bone marrow transplantation laid the foundation for developing CAR-T therapy, as it was the first time that living cells were infused into blood cancer patients for the control of cancer.

As early as 1900s, researchers were becoming aware that T cells could easily search, recognize and kill cancer cells. To do this, the cells need a “guide” to direct them to the tumors, and thus, antibodies emerged as a valuable scientific and medical tool. [Read more…]

Filed Under: CAR-T Tagged With: CAR-T

Types of CAR-T Cells: Improvements in CAR Design and Construction

March 6, 2020 By Marie Carroll

Types of CAR-T Cells

What are the types of CAR-T cells and how have they changed in recent years? CAR-T cells are immune cells that are artificially engineered to express a particular chimeric antigen receptor (CAR), which have shown great potential in killing cancer cells. Chimeric antigen receptors (CARs) are artificially produced recombinant receptors having both antigen-binding and T-cell activating potentials.

CARs are composed of an extracellular recognition domain sourced from monoclonal antibodies (mAbs) and an intracellular signaling domain including CD3- and costimulatory domains for triggering endogenous signaling pathways of T-cells. [Read more…]

Filed Under: CAR-T Tagged With: CAR-T

Genetic Modification of CAR-T Cells

February 16, 2020 By Cade Hildreth (CEO)

genetic modification of CAR-T

Chimeric antigen receptor-modified T (CAR-T) cells are living therapies that are genetically engineered to express CAR molecules targeting antigens found on tumor cells or target cells of interest. Unfortunately, an obstacle for the field of CAR-T cell therapy is limited CAR T cell persistence after infusion into cancer patients. Thus, genetic engineering strategies to improve CAR T cell persistence will be central to the success of these gene-modified cellular therapies. [Read more…]

Filed Under: CAR-T Tagged With: CAR-T

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