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Breakdown of Mesenchymal Stem Cell Clinical Trials, by Phase, Geography, Sponsors, and More

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Historical Number of Mesenchymal Stem Cell Clinical Trials (IFCB)

In 2014, the International Federation for Cell Biology (IFCB) conducted an analysis of mesenchymal stem cell clinical trials, identifying that 313 clinical trials involved mesenchymal stem cells (MSCs). The majority of these clinical trials (41.7%) were in Phase I/II. Another  23.7% of these studies were in Phase II. However, only 4.2% of these clinical trials had progressed to Phase III. As such, it is clear that the bulk of MSC clinical trials remain in the early stages of development.

Among the clinical trials that progressed through Phase III, one of the most promising stem cell therapies to emerge was Prochymal, an allogenic mesenchymal stem cell therapy derived from the bone marrow of adult donors and made by Osiris Therapeutics. Prochymal is produced by purifying MSCs from the bone marrow of donors, then culturing and packaging the cells, allowing up to 10,000 doses to be derived from a single donor.  [Read more…]

Epic Year for Regenerative Medicine Investments

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In the past twelve months, regenerative medicine investments gained momentum, as new and promising clinical data got released. The momentum has been growing in recent years, enabling the cell therapy and genome editing sectors to evolve into a global industry.

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Mesenchymal Stem Cell Industry News Round Up | July 2015

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The mesenchymal stem cell industry is well-known for its shifting dynamics, including new alliances, new research advances and innovations. Every month there are major new events that affect market participants.

While it may be possible to stay informed about mesenchymal stem cell industry news in your region, it can be more difficult to track changes on a global scale. For that reason, the following is a summary of significant mesenchymal stem cell industry events for July 2015.

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Mesenchymal Stem Cell Industry News Round Up | June 2015

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The mesenchymal stem cell industry is well-known for its shifting dynamics, including new alliances, new research advances and innovations. Every month there are major new events that affect market participants.

While it may be possible to stay informed about mesenchymal stem cell industry news in your region, it can be more difficult to track changes on a global scale. For that reason, the following is a summary of significant mesenchymal stem cell industry events for June 2015.

[Read more…]

Adult and Fetal Isolation Sources for Mesenchymal Stem Cells (MSCs)

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Mesenchymal stem cells can be derived from a diverse range of tissues. Originally, Friedenstein et al. isolated MSCs from the bone marrow (BM) and stroma of the spleen and thymus.[1][2] MSCs have since been derived from tissues as varied as the brain, spleen, liver, kidney, lung, bone marrow, muscle, thymus, and pancreas.[3]  However, bone marrow aspirates are still considered to be the most convenient and enriched source of MSCs.[4]

Fetal tissue also contains MSCs, with common sources including umbilical cord blood and fetal placenta. These sources may represent ontogenetically younger MSCs. Evidence exists that MSCs from fetal sources can undergo more cell divisions before they reach senescence than MSCs from adult tissue.[5] [Read more…]

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