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Geographic “Hotspots” for Exosome Clinical Trials

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As exosomes become recognized for their benefits as cell-free therapeutics, exosome clinical trials are increasing in number. Exosomes are small vesicles ranging from 30-100nm in size that are found in nearly all eukaryotic fluids and facilitate a range of important cellular functions. They transfer DNA, RNA, and proteins to other cells, altering the function of target cells.

Exosome Clinical Trials

In addition to increasing in number, exosome clinical trials are tightly concentrated within specific regions of the world.

There are now 92 trials listed on ClinicalTrials.gov that contain the term “exosome” or “exosomes.” [Read more…]

Bio-Techne Acquires Exosome Diagnostics for $250M Cash Plus Milestones

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bio-techneOn June 25, 2018, Bio-Techne announced it is acquiring Exosome Diagnostics for $250 million in cash and up to $325 million for achieving certain milestones. As exosome therapeutics and diagnostics have multiplied in number, a number of investors have placed big bets on this rapidly growing marketplace.

Exosomes are small vesicles ranging from 30-100nm in size that are secreted by nearly all cell types. They facilitate a range of important cellular functions, including facilitating intercellular communication.  [Read more…]

How Exosomes Are Revolutionizing Neuroimmunology with Dr. Stefano Pluchino

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Dr Stefano Pluchino - Pluchino Lab
Dr. Stefano Pluchino of the Pluchino Lab in Cambrige

I am honored to release this interview with Dr. Stefano Pluchino of the highly regarded Pluchino Lab in Cambridge, UK. Dr. Pluchino received his MD and PhD degrees at the University of Siena, Italy, and additional training at Cambridge University, UK.

Dr. Pluchino is an international expert on neuroimmunology-related applications of exosomes, with his lab exploring modalities by which neural progenitor cells (NPCs) engage in cell-to-cell communication. The focus of the laboratory is to explore cellular and molecular mechanisms regulating to the therapeutic plasticity of stem cells in preclinical models of CNS conditions, including multiple sclerosis (MS), stroke, and spinal cord injury. [Read more…]

Exosome Market Forces

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Exosome-related technologies have been developing rapidly over the past few years and substantial growth is expected for the market as they get integrated into the fields of liquid biopsy, precision medicine and regenerative medicine.

In particular, cancer derived exosomes influence the invasive potential of cells by regulating angiogenesis, metastasis, and immunity, making them an extremely useful source of biomarkers for use in cancer detection, diagnosis, and therapeutic selection. [Read more…]

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