Currently over 50% of men and women are directed to unnecessary treatment or surgery. A new approach may help. Professor Alan Doucette of Dalhousie University and his colleagues have published a study funded by the Breast Cancer Society of Canada in which they capture particles released by rapidly growing cells called exosomes. Like parcels containing tools and instructions, exosomes contain an “inventory of intent.” Meaning, the cells that have released them contain genetic material proteins and metabolites that promote invasion of normal cells and commandeer their resources. [Read more…]
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Axol Bioscience Secures SMART Grant to Accelerate the Development of a Commercial iPSC-Powered ALS Models
Axol Bioscience has been awarded a SMART Grant by Scottish Enterprise to Accelerate ALS Research through the development of ALS-related phenotypes using human iPSCs. This represents another significant step towards better disease modelling and ALS drug discovery.
The key objectives of this project are to:
- Develop a quality manufacturing system for iPSC-derived ALS relevant cell types
- Characterise and validate the cells using ALS relevant end points; TDP43 aggregation, Neurofilament Light elevation and Cryptic Exon Sequencing
- Develop and characterise an ALS co-culture model which includes motor neurons, microglia and astrocytes
- Commercialise an easy-to-use model system to drive forward ALS drug discovery
Interview with Patrick Lucy, President and CEO of Lykan Bioscience
This is an interview with Patrick Lucy, President and CEO of Lykan Bioscience. Lykan is an innovative cell therapy-focused contract development and manufacturing organization (CDMO) headquartered in Hopkinton, MA. In this interview, we discuss the vision of Lykan Bioscience, its innovative and agile approach to CDMO services, and the company’s future goals. Enjoy! [Read more…]
Leveraging MSC-Derived Exosomes for the Treatment of Autism?
With autism spectrum disorder (ASD) affecting between 1-2% of the population and affecting all racial, ethnic, and socioeconomic groups, the condition is becoming of global importance. While the pharma industry has not yet been able to deliver a solution for this disease, the cell therapy industry is now undertaking the challenge. [Read more…]
Answer ALS Releases World’s Largest ALS Patient-Based iPSC and Bio Data Repository
Unprecedented resource, created with Cedars-Sinai, to accelerate ALS research and drive development of targeted therapies globally
NEW ORLEANS –In a landmark continuing collaboration, Answer ALS and Cedars-Sinai have announced the completed availability of the largest amyotrophic lateral sclerosis (ALS) patient-based induced pluripotent stem cell (iPSC) and bio data repository. The repository encompasses biological and clinical data from nearly 1,000 ALS patients, offering an unprecedented resource for global researchers studying ALS, commonly known as Lou Gehrig’s disease. [Read more…]
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