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MD Anderson and NIH to Fund Clinical Trial Combining 2 Mesoblast Technologies

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On December 6th, MD Anderson Cancer Center and NIH announced that they will be funding a clinical trial that will combine two Mesoblast technologies:

  1. Mesenchymal Precursor Cell (MPC)-based expansion
  2. Ex-vivo fucosylation of hematopoietic stem cells (HSCs) for cord blood transplantation in cancer patients

The purpose of the trial is to provide clinical data to indicate whether these technologies can interact synergistically to promote faster cord blood HSC engraftment for bone marrow transplant patients. [Read more…]

What Types of Mesenchymal Stem Cell (MSC) Research Are Getting Funded?

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To analyze trends within the mesenchymal stem cell (MSC) industry, it is valuable to consider grant rate data. Previously, the U.S. federal government operated an online tool called CRISP (“Computer Retrieval of Information on Scientific Projects”). It was a searchable database of federally funded biomedical research projects conducted at universities, hospitals, and other U.S. research institutions. The database allowed users to search the CRISP interface for grants funding for specific types of scientific research, using text-based search terms.

However, that has since been replaced by RePORTer (Research Portfolio Online Reporting Tools)1, a more powerful database and search tool supported by the U.S. Department of Health and Human Services. RePORTer allows users to search a comprehensive repository of National Institutes of Health (NIH) funded research projects resulting from NIH funding. [Read more…]

Mesenchymal Stem Cells Surpass Hematopoietic Stem Cells in the Scientific Literature

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Five of the most commonly used stem cell types that are used for research purposes are embryonic stem cells, mesenchymal stem cells, hematopoietic stem cells, neural stem cells, and induced pluripotent stem cells.

Therefore, the analysis below considers trends in scientific publication rates for these five stem cell types, over a trailing five-year history. PubMed.gov scientific publication rate data is used for this analysis because of its comprehensive nature.1

PubMed is a service of the U.S. National Library of Medicine and the National Institutes of Health (NIH) that includes over 19 million citations from MEDLINE and other life science journals that date back to the 1950s.2 It is the leading search engine through which to search scientific publications, as NIH researchers are mandated by law to submit their research and most external research is submitted as well, either voluntarily or by mandate.3

TABLE. Comparison of Stem Cell Publication Rates, by Stem Cell Type (Five-Year Historical)
TABLE. Comparison of Stem Cell Publication Rates, by Stem Cell Type (Five-Year Historical)

Year-Over-Year Comparison of Stem Cell Scientific Publications, by Stem Cell Type

Comparison of Stem Cell Research Frequency, by Stem Cell Type

As observed in the graph above, hematopoietic stem cells were the most frequent type of stem cells to be cited in the scientific literature through 2014. Mesenchymal stem cells were the second most common stem cell type through 2014.

In 2015, mesenchymal stem cells surpassed hematopoietic stem cells to become the most common stem cell type to appear within the scientific literature.

This is the first time in history that mesenchymal stem cells substantially outpaced hematopoietic stem cells within the scientific literature.

Additionally, mesenchymal stem cells are the only stem cell type of the five analyzed that had an increase in scientific publications from 2014 to 2015.

All four of the other stem cell types decreased in scientific publication frequency during that period.

Embryonic stem cell research came in third place among the five stem cell types that were analyzed, while neural stem cells and induced pluripotent stem cells both showed lower rates of scientific publications over a trailing five-year period.

Footnotes: 
1Source: Pubmed, http://www.ncbi.nlm.nih.gov/pubmed/. Search Terms: 1) “Embyronic Stem Cell” OR “Embryonic Stem Cells”; 2) “Mesenchymal Stem Cell” OR “Mesenchymal Stem Cells”; 3) “Hematopoietic Stem Cell” OR “Hematopoietic Stem Cells”; 4) “Neural Stem Cell” OR “Neural Stem Cells”; 5) “Induced Pluripotent Stem Cell” OR “Induced Pluripotent Stem Cell” OR “iPSC” OR “iPSCs”. Search Executed: January 24, 2106.
2Ncbi.nlm.nih.gov. 2014. Home – PubMed – NCBI. Available at: http://www.ncbi.nlm.nih.gov/pubmed/. Web . 29 Jan. 2016.
3Science Codex. Available at: http://www.sciencecodex.com/public_access _mandate_made_law. Web. 29 Jan. 2016.

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