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Mesoblast & Cartherics to Produce Allogeneic CAR-T Cells from Gene-Edited iPS Cells

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Mesoblast Partners With Cartherics to Develop ’off-the-shelf’ Cell-based Immunotherapies for Solid Cancers

Relapsed Ovarian and Gastric Cancers Initial Targets for Allogeneic CAR-T Cells

NEW YORK and MELBOURNE, Australia, May 29, 2018 — Mesoblast Limited (Nasdaq:MESO) (ASX:MSB) today announced that it has entered into a partnership with Cartherics Pty Ltd to develop allogeneic ‘off-the-shelf’ CAR-T cells armed with multiple targeting receptors for use in solid cancers. Off the shelf CAR-T therapies have the potential to reduce costs dramatically and open up this very effective treatment to millions of cancer patients across the world. The initial targets are relapsed ovarian and gastric cancers. Mesoblast and Cartherics will jointly own the intellectual property produced using their combined technologies. [Read more…]

Celularity – Big Bucks, Billionaire Investors, Bold Dreams

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Celularity Celularity is a biotechnology company that specializes in leveraging biologically active cell populations within the postpartum human placenta. Founded on the pioneering work of Robert Hariri, MD, PhD, in human placenta-derived cellular therapeutics and biomaterials, Celularity is uniquely positioned to harness the potential of most biocreative event on earth: human birth.

I had the honor of interviewing Celularity’s CEO, Dr. Robert Hariri, a pioneer and visionary within the stem cell industry. As a surgeon, biomedical scientist and serial entrepreneur, Dr. Hariri was previously the Founder and CEO of one of the world’s largest human cellular therapeutics companies, Celgene Cellular Therapeutics, a division of Celgene Corporation. In August 2017, Hariri brought Celularity Inc. into the spotlight by announcing a successful Series A financing with contributions from influential investors, including Sorrento Therapeutics, United Therapeutics Corporation, and Human Longevity, Inc. (HLI).

On February 15th, 2018, the company broke even bigger news when it announced that it had raised $250 million in funding, with contributions from the Genting Group, Tony Robbins, and Dreyfus Family Office, among others.

Below is Part 2 of a two-part interview with Celularity’s CEO, Dr. Robert Hariri. Click here to read Part 1.

[Read more…]

Kite Pharma Execs Form Allogene with Pfizer’s CAR-T Assets and $300M

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  • Creates alliance with Allogene Therapeutics, a biotechnology company co-founded and led by former executives of Kite Pharma that is positioned to expedite the development of allogeneic CAR T cell therapy

  • Allogene Therapeutics, a Two River portfolio company, was formed with one of the largest Series A financings in biotechnology of $300 million from a premier investment consortium that includes TPG, Vida Ventures, BellCo Capital, the University of California Office of the Chief Investment Officer and Pfizer

  • Pfizer will hold a 25 percent ownership stake in Allogene Therapeutics

NEW YORK & SOUTH SAN FRANCISCO–Pfizer Inc. (NYSE:PFE) and Allogene Therapeutics, Inc. (Allogene) today announced that the two companies have entered into an asset contribution agreement for Pfizer’s portfolio of assets related to allogeneic chimeric antigen receptor T cell (CAR T) therapy, an investigational immune cell therapy approach to treating cancer.
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Cesca Therapeutics is making BIG moves to dominate the CAR-T space

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Cesca Therapeutics

Cesca Therapeutics is making big moves to become a player in the CAR-T space. In recent months it filed a a patent application for innovation to its CAR-TXpress™ technology, signed a license agreement with China’s IncoCell Tianjin Ltd. for CAR-T related CDMO services in Asia, and is continuing development of Thermogenesis’ novel CAR-TXpress platform.

The company also recently announced the launch of its 2nd gen AXP® II system for isolating and collecting hematopoietic stem cells (HSCs) from umbilical cord blood and peripheral blood. Since the launch of its first AXP® system, Cesca has been a leader is cord blood processing technologies.

[Read more…]

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