Cynata Therapeutics (ASX: CYP) has executed a term sheet with FUJIFILM Corporation of Japan for the development and commercialisation of certain Cynata technology, including Cynata’s lead product, CYP-001. CYP-001 is an induced pluripotent stem cell (iPSC) derived mesenchymal stem cell (MSC) product that is anticipated to be the first allogeneic iPSC product to enter a clinical trial.
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Dominance of Cellular Dynamics International (CDI) within iPSC Marketplace
Cellular Dynamics International (CDI), a FUJIFILM company, is the largest provider of induced pluripotent stem cell (iPSC) products worldwide. iPSCs are a type of laboratory made stem cell that has significant potential for use within regenerative medicine.
Theoretically, iPSCs have the potential to treat a wide range of diseases, including diabetes, heart diseases, autoimmune diseases, neural decline and more. iPSCs are also being widely implemented for use in drug development and discovery, as well as toxicology screening and personalized medicine.
In this article:
- Life Science Business Unit
- iPSC Market Competitors
- Cellular Dynamics International, Owned by Fujifilm Holdings
- Cellular Dynamics and Shinya Yamanaka
- Cellular Dynamics International Product Licenses
- An Important Player in Stem Cell Research and Therapy
- Use of iPSCs in Drug Development and Discovery
- CDI’s Acquisition by FUJIFILM Holdings Corporation
- The Advantage of Cellular Dynamics’ Fujifilm Acquisition
- Where Will CDI Focus iPSC Cell Production Technology?
Cellular Dynamics International and iPSC Therapy
Since September 2016, Cellular Dynamics International (CDI) has been divided into two business units, a Therapeutics Business Unit and a Life Science business unit. CDI’s Therapeutics business unit is focused on developing induced pluripotent stem cell (iPSC) based therapies for ocular, cardiac, neural and oncology applications. In contrast, CDI’s Life Science business unit is focused on developing the research products side of the business.
iPSC Market Competitors
In addition to CDI, there are many other companies and organizations that are involved with the development of induced pluripotent stem cell (iPSC) therapies, including but not limited to:
- Ocata Therapeutics
- RIKEN
- Kyoto University and CiRA
- Fate Therapeutics
- Megakaryon Corporation
- Cynata Therapeutics
There are also a number of companies specializing in iPSC product development, including:
- Allele Biotechnology
- ALSTEM Bio
- Applied Biological Materials (ABM)
- Applied StemCell
- Axol Bioscience
- BrainXell
- Cell Applications
- Cellular Dynamics International (a Fujifilm Company)
- EMD Millipore
- Minerva Biotechnologies
- Ncardia (formed through merger of Axiogenesis and Pluriomics)
- Neucyte
- Pluricell Biotech
- REPROCELL
- Sigma Aldrich (provides 350 iPSC lines through partnership with EBiSC)
- STEMCELL Technologies
- Stemgent (iPS Cell Business Unit owned by ReproCELL)
- Takara Bio
- Tempo Bioscience
- Thermo Fisher Scientific
- xCell Sciences
- And others
Fujifilm Cellular Dynamics Inc
Cellular Dynamics International is one of the most important market participants in the iPSC sector, because of its dominance in both iPSC therapies and life science tools.
Mesoblast Securing IP Portfolio for Use of Mesenchymal Precursor Cells
Mesoblast has been granted a key patent by the United States Patent and Trademark Office (USPTO) for use of its Mesenchymal Precursor Cells (MPCs) in the treatment of rheumatic diseases, including rheumatoid arthritis (RA). Mesoblast is global company that specializes in developing cell-based therapies that utilize mesenchymal precursor cells (MPCs) and mesenchymal stem cells (MSCs).
The Company’s patent portfolio in the United States for the treatment of RA and related conditions “comprises the newly and recently granted patents, US 9,381,216 and US 9,265,796, which cover treatment of rheumatic diseases by administration of STRO-1 positive MPCs.”
According to Dr. Allan Gibofsky, Professor at Weill Cornell Medical College, “The trial used standardized parameters consistent with United States Food and Drug Administration (FDA) guidance for RA product development. Importantly, there was consistency observed in the dose-related responses for clinical symptoms, physical function and disease activity parameters at 12 weeks in line with the trial’s pre-specified efficacy endpoints.”
To learn more, view the Mesoblast press announcement.
Bioquark Inc. and RegenerAge SAPI de CV to Collaborate on Clinical Regenerative Healthcare
Bioquark Inc. and RegenerAge SAPI de CV will focus on translational therapeutic applications of a range of regenerative and rejuvenation based healthcare interventions, with the goal of reducing human degeneration, suffering, and death.
Philadelphia, PA, USA/ Mexico City, Mexico; JULY 19, 2016 – Bioquark, Inc., a life sciences company focused on the development of novel bioproducts for complex regeneration, disease reversion, and aging, and RegenerAge SAPI de CV, a clinical company focused on translational therapeutic applications of a range of regenerative and rejuvenative healthcare interventions, have announced a collaboration to focus on novel combinatorial approaches in human disease and wellness. SGR-Especializada (http://www.sgr-especializada.com/), regulatory experts in the Latin American healthcare market, assisted in the relationship.
“We are very excited about this collaboration with RegenerAge SAPI de CV,” said Ira S. Pastor, CEO, Bioquark Inc. “The natural synergy of our cellular and biologic to applications of regenerative and rejuvenative medicine will make for novel and transformational opportunities in a range of degenerative disorders.” [Read more…]
Landmark Stem Cell Clinical Trial Testing Escalating Doses of AST-OPC1 (Oligodendrocyte Progenitors)
Below is a press release from Santa Clara Valley Medical Center (SCVMC), a site in the AST-OPC1 SCiSTAR Phase 1/2a clinical trial in complete cervical spinal cord injury, which is being sponsored by BioTime, Inc. (NYSE MKT: BTX) subsidiary Asterias Biotherapeutics (NYSE MKT: AST).
The clinical trial will test the safety of three varying doses of AST-OPC1, which are oligodendrocyte progenitors that have the capacity to differentiate into a variety of brain cells. The California Institute of Regenerative Medicine (CIRM) also released a blog post about the procedure conducted at SCVMC.
The SCiSTAR study being run by Asterias Biotherapeutics is funded in part by a $14.3 million grant from CIRM. [Read more…]
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