Bridging the Gap: Streamlining iPSC-Derived Cell Line Development from Donor Cells to MCB
Allogeneic iPSC-derived therapies hold immense promise, offering scalable, off-the-shelf solutions for a wide spectrum of diseases. However, the journey from donor cells to a gene edited, clinically compliant GMP Master Cell Bank (MCB) is fraught with challenges and is particularly vulnerable to risks stemming from misaligned early development.
A major bottleneck seen in the majority of iPSC therapeutic programs arises when development teams continue to rely on R&D grade cell lines to confirm proof-of-concept, conduct preclinical animal studies, and to start process & analytical development. [Read more…]
What is CAR-T Cell Therapy? A New Way to Treat Cancer
CAR-T cell therapy is as a type of immunotherapy that teaches T cells to recognize and destroy cancer. CAR-T cell therapy has demonstrated promising results in a range of patients across the globe. In some patients, this can lead to the total elimination of the cancer. In others, there is a significant improvement of the disease.
For those confronting cancer, one crucial question often arises: What is CAR-T cell therapy? This guide answers the most common questions and explains how this innovative technology is transforming the future of cancer treatment.
List of U.S. FDA Approved Cell and Gene Therapy Products (46)
Today, researchers and clinicians are under great pressure to develop therapies capable of reversing or significantly impacting the progression of disease. In recent years, the arrival of the cell and gene therapy industries have introduced the possibility of providing transformative, durable and potentially curative outcomes for a diverse range of life-threatening conditions, as well as injuries, degenerative diseases, genetic disorders, and cancers. [Read more…]
Who Discovered Stem Cells? The Answers Revealed
Who discovered stem cells is a question that invites both historical and scientific exploration. While Robert Hooke is credited with first observing cells in the 17th century, the discovery of stem cells themselves is generally attributed to Drs. James Till and Ernest McCulloch in the 1960s.
For hundreds of years, scientists have understood that the human body is made up of trillions of microscopic structures called cells. These cells exist in more than 200 distinct types, each performing vital functions such as pumping blood, digesting food, transmitting nerve signals, and eliminating waste and toxins from the body. Stem cells are unique among these cells because they have the ability to develop into many different cell types, making them a cornerstone of modern regenerative medicine and biomedical research.
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