Happy Holidays! I hope you are enjoying this exciting season with family, friends, colleagues, and lots of holiday cheer. As you celebrate and reflect on a prosperous 2016, we have posted new stem cell industry coverage to help you prepare for 2017. This week in stem cells we cover cell therapy in Asia, exosomes going exponential, a massive $225M series A financing, and much more. [Read more…]
Bayer and Versant Co-Invest $225M to Launch BlueRock Therapeutics
— BlueRock Therapeutics is focused on breakthrough treatments based on latest stem cell technology in combination with superior cell differentiation protocols
— BlueRock Therapeutics’ vision is to cure diseases with significant cell loss and diminished self-repair potential with an initial focus on cardiovascular, neurological and other conditions
Allen Institute for Cell Science Releases Gene Edited Human Stem Cell Lines
First 5 cell lines in Allen Cell Collection empower the cell science community to explore the dynamic organization of the cell and to better understand health and disease
November 30, 2016 — The Allen Institute for Cell Science has released the Allen Cell Collection: the first publicly available collection of gene edited, fluorescently tagged human induced pluripotent stem cells that target key cellular structures with unprecedented clarity. Distributed through the Coriell Institute for Medical Research, these powerful tools are a crucial first step toward visualizing the dynamic organization of cells to better understand what makes human cells healthy and what goes wrong in disease.
“Each of our cells—the fundamental units of life—are like a city, with people and resources that move around and factories that generate those resources and carry out important functions,” says Rick Horwitz, Ph.D., Executive Director of the Allen Institute for Cell Science. “With these cell lines, we aim to give the cell science community a kind of live traffic map to see when and where the parts of the cell are with the clarity and consistency they need to make progress toward understanding human health and tackling disease. [Read more…]
Using HLA “Super Donors”, ORIG3N’s Crowdsourced Cell Repository Contains Donor Matches for 90% of U.S.
ORIG3N announced it has identified “super donor” matches for 90 percent of the U.S. population. The discovery will accelerate how quickly and successfully we match people for transplants, as tissue can be generated from these cells. ORIG3N was able to achieve this milestone approximately 5x faster than its Japanese counter parts because it has built the world’s largest crowdsourced cell repository called LifeCapsule.
HLA is short for “human leukocyte antigen.” It is a gene complex encoding the cell-surface proteins that control regulation of the human immune system. More simply, it is a protein found on most cells of your body that determines how your body recognizes what is you versus other.
HLA “super donors” are people with tissues that are immunologically compatible with a large percentage of the human population. They are very rare in the population, making them difficult to identify.
The signficanceof this announcement by ORIG3N is that for the first time in history, a complete set of matched samples has been identified and can be industrially produced. Utilizing induced pluripotent stem cell (iPSC) technology, any of the 200+ tissues that compose the human body can now be created.
Importantly, these tissues would be an exact match to the individuals requiring them, even though they were derived from another person (an allogenic transplant).
According to ORIG3N, in the near future, this approach may allow people to rapidly get an exact match for a transplant, instead of waiting for months. Instead, tissues could be “pre-produced.”
For more information, visit www.orig3n.com.
Cynata’s “Major Breakthrough” in MSC Manufacturing – Unlimited Quantities, Uniform Batches, Single Donor, & Low Cost
For years, it has been clear that mesenchymal stem cells (MSCs) are a leading type of stem cell being investigated for therapeutic applications, as they have the potential to treat a wide range of acute and degenerative diseases. In addition to secreting factors that can stimulate tissue repair, MSCs can substantially alter their microenvironment, exerting effects that are both anti-inflammatory and anti-fibrotic.
MSCs are also advantageous over other stem cells types, because they avoid the ethical issues that surround embryonic stem cell research and appear to be immuno-privileged. Importantly, MSCs also well-suited for use in the exponential growth area of 3D printing, because of their unusual capacity to form structural tissues. [Read more…]
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