BrainStorm Strengthens Exosome Patent Portfolio: Receives Notice of Allowance for U.S. Patent Covering Its Platform Technology
NEW YORK, Dec. 3, 2024 — BrainStorm Cell Therapeutics Inc. (NASDAQ: BCLI), a leading developer of adult stem cell therapeutics for neurodegenerative diseases, announced today that it has received Notice of Allowance from the U.S. Patent & Trademark Office (USPTO) for patent application 16/981,757 which covers its proprietary exosome technology. [Read more…]
What is the Current State of Stem Cell Derived Exosomes?
Prior to 2007, exosomes were largely considered to be tiny “trash sacs” thrown out of living cells. Around 2007, it as discovered that exosomes carry RNAs and miRNAs, along with other molecules to regulate the expression of genes between cells. This discovery paved the way for the scientists to search for improved techniques for the exploitation of exosomes in treating diseases. [Read more…]
Taking EV characterization to the next level with ONI’s Nanoimager
Extracellular vesicles (EVs) are known for their role in facilitating wide range of intercellular communication such as regulation of the immune response and stem cells differentiation.
What is an extra-cellular vesicle?
EVs are membrane-enclosed particles ranging in size from 30nm to 300nm and their characteristic depend on the cell type releasing them. Often they will carry cargo of active molecules like RNA, DNA, proteins, metabolites and lipids. Moreover, EVs can be found in most biological fluids with the ability to cross biological barriers, and in the case of pathological conditions, the composition of the cargo will be distinctive to the disease. Altogether, these features have led to intense research into the potential role of EVs for diagnostics, biomarkers and as vehicles for drug delivery. [Read more…]
Exosomes as a New Class of Cell-Free Therapeutics and Diagnostics
Exosomes are extracellular vesicles (EVs) of endosomal origin that range in size between 30 and 150 nanometers (nm). Exosomes are formed by the invagination of the cell membrane. This invagination and subsequent budding result in the formation of early endosomes. These early endosomes then mature into late endosomes, which are also called multivesicular bodies (MVBs). Finally, these MVBs migrate and fuse with the plasma membrane to release exosomes outside the cell. [Read more…]
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