Groundbreaking experimentation in 2006 led to the introduction of induced pluripotent stem cells (iPSCs). These are adult cells which are isolated and then transformed into embryonic-like stem cells through the manipulation of gene expression, as well as other methods. Research and experimentation using mouse cells by Shinya Yamanaka’s lab at Kyoto University in Japan was the first instance in which there was successful generation of iPSCs.[1] In 2007, a series of follow-up experiments was done at Kyoto University in which human adult cells were transformed into iPSC cells. [2] Nearly simultaneously, a research group led by James Thomson at the University of Wisconsin-Madison accomplished the same feat of deriving iPSC lines from human somatic cells.[3] [Read more…]
Legendary NFL Quarterback Bernie Kosar Launches X Pro. Athlete Cognitive Longevity Wellness Program to Push the Limits of Brain Performance with Crowley Center for Regenerative Biotherapeutics in collaboration with global biotech manufacturer Regenerelle®, LLC, and trial sponsor The Crowley Center for Regenerative Biotherapeutics, LLC.
Backed by a $10M Age Zero™ Regenerelle® in-kind contribution by the Crowley Family, Team Bernie™ brings together NFL veterans and longevity innovators to explore next-generation cognitive optimization.
COLUMBUS, OH / FORT LAUDERDALE, FL / ROCHESTER, NY, October 23, 2025 – In a world focused on optimizing the body — from cold plunges to peptides — one team is taking on the next frontier: the brain.
Renewing Athletes’ Lives™ (RAL), co-founded by Michael Crowley, Erin Crowley, and Bernie Kosar, today announced the launch of Team Bernie™, a Cognitive Longevity Program exploring how targeted brain-support strategies may help athletes sharpen focus, clarity, and mental resilience long after their playing careers ends. [Read more…]
How Regenerative and Cellular Medicine are Transforming the Lives of Older Adults
The healthcare industry faces challenges in meeting the needs of older adults. Conventional medical practices struggle to provide comprehensive solutions for age-related issues. These innovative fields aim to improve the quality of life for seniors by addressing the underlying causes of various ailments. [Read more…]
iPSC Applications in Cell Therapy, Drug Discovery, and Beyond
Since the discovery of induced pluripotent stem cell (iPSC) technology 18 years ago, significant progress has been made in stem cell biology and regenerative medicine. New pathological mechanisms have been identified, new drugs identified by iPSC screens are in the pipeline, and the first clinical trials employing human iPSC-derived cell types have been initiated. [Read more…]
iPSCs are Transforming Drug Discovery, Toxicity Testing, Disease Modeling, and Beyond
Induced pluripotent stem cells (iPS cells or iPSCs) are laboratory-made pluripotent stem cells that are produced using adult cells. They are derived from somatic cells by reprogramming artificially and turning on the expression of specific pluripotency genes. The reprogramming is achieved using different techniques with varying efficiencies. The iPSC technology was first discovered in 2006 by Shinya Yamanaka’s lab in Kyoto, Japan. He and his team introduced four specific genes encoding transcription factors and converted adult cells into pluripotent stem cells. [Read more…]
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