I am honored to release this interview with Bobby Ardila, V.P. of International Medical Communications for Neo Matrix, LLC. Neo Matrix is a newly formed cell therapy company serving the U.S.A. and South American markets. In this interview, we explore the company’s use of a placental tissue matrix component for regenerative medicine applications.
Top 10 Differentiators for Axiogenesis within the Global iPSC Marketplace
Groundbreaking experimentation in 2006 by Shinya Yamanaka (Kyoto University, Japan) led to the introduction of induced pluripotent stem cells (iPSCs). These are adult cells that are isolated and then reprogrammed into embryonic-like stem cells through the expression of a specific set of embryonic genes. Yamanaka’s discovery, which earned him the Nobel prize in 2012, enabled the use of human cells in stem cell science, bypassing the use of embryonic stem cells (ESCs). Without the ethical problems associated with ESCs, a large and diverse market for human iPSC research tools has emerged.
Founded in 2001 and headquartered in Cologne, Germany, Axiogenesis initially focused on generating mouse embryonic stem cell derived cells and assays. After Yamanaka’s groundbreaking iPSC technology became available, Axiogenesis was the first European company to license and adopt Yamanaka’s iPSC technology in 2010. [Read more…]
Reversing Type I Diabetes with Encapsulated Cell Therapy Technology
This is an interview with Gary Harlem, CEO of Altucell, a company exploring novel cell therapy approaches to treating Type I diabetes. In addition to diabetes, the company’s core encapsulation technology is applicable to a wide range of autoimmune and chronic degenerative disorders.
While Altucell is an American company, it has secured intellectual property rights on encapsulation patents from a team of researchers at the University of Perugia, Italy, led by Dr. Riccardo Calafiore, M.D. [Read more…]
High-Volume 3D Printing of Living Stem Cells – Proof-of-Concept Established by Nano Dimension and Accellta
Recently, I had the honor of interviewing Dr. Itzchak Angel, CEO of the Israeli stem cell company, Accellta Ltd. Accellta is introducing a paradigm shift to the stem cell marketplace by quickly, efficiently, and cost-effectively growing massive quantities of clinical grade cells in xeno-free, feeder-free culture. Based in Haifa, Israel, Dr. Angel leads a team of executives and researches who are world-renowned experts at growing stem cells in suspension.
In major news released today, Nano Dimension Ltd. announced it has successfully “lab-tested a proof of concept 3D bioprinter for stem cells” in collaboration with Accellta Ltd. Nano Dimension Ltd. specializes in 3D printing systems, while Accellta uses 3D bioreactors to grow large numbers of cells in suspension. Specifically, Accellta can increase a cell population from 1 million cells to 10 billion cells in two weeks with an overall cost of about $3,000, by using bioreactors to do it in a very efficient way. Using traditional adherent culture, it would cost of $150,000 and take 40 to 50 days. [Read more…]
Sistemic and Cynata to Collaborate on an In-process Purity Assay for Cynata’s iPSC-Derived Mesenchymal Stem Cells
Based in Glasgow, UK, Sistemic Ltd. is a company that specializes in microRNA-based services and kit-based products. Cynata Therapeutics is a stem cell and regenerative medicine company listed on the Australian stock exchange (ASX: CYP).
Cynata’s Cymerus™ technology utilizes iPSCs originating from an adult donor as the starting material for generating mesenchymal stem cells (MSCs). The importance of this technology is that it is a process for manufacturing a consistent cell therapy product.
Cynata’s lead product is CYP-oo1, an iPSC-derived mesenchymal stem cell product that is anticipated to be the world’s first allogeneic iPSC product to enter a clinical trial.
In the press release below, Sistemic Ltd. and Cynata Therapeutics announce that they have entered into an agreement in which Sistemic will use its miRNA technology platforms to develop an in-process assessment assay for Cynata’s Cymerus™ cell therapy products.
MSCs are currently being explored in nearly 500 clinical trials worldwide, but technologies supporting large-scale manufacturing of MSCs are scare, which is what makes standardization and scale-up of the Cymerus technology important.
To learn more, read the full press release issued by Sistemic Ltd. below. [Read more…]
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