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Scientists demonstrate enhanced healing capabilities of stem cells in groundbreaking research
Olathe, KS – Ronawk, a biotech and biofabrication company powered by the Bio-Block Universe™, is pleased to announce a groundbreaking new study titled “Tissue-mimetic culture enhances mesenchymal stem cell secretome capacity to improve regenerative activity of keratinocytes and fibroblasts in vitro” which has been published in the flagship journal, Wound Repair and Regeneration, of the Wound Healing Society.
The study, led by researchers Jacob G. Hodge Ph.D., Heather E. Decker BA, Jennifer L. Robinson Ph.D., and Adam J. Mellott Ph.D., showcases significant advances in regenerative medicine, particularly concerning the healing capabilities of mesenchymal stem cells (MSCs).
The peer-reviewed paper, first published on March 3, 2023, can be accessed at https://onlinelibrary.wiley.com/doi/10.1111/wrr.13076. The research was supported by the National Institute of General Medical Sciences, under Grant/Award Number R35GM143081.
The study focused on the use of tissue-mimetic culture, a method that imitates the environment found in living organisms, to enhance the secretome capacity of MSCs. The secretome comprises a complex mixture of proteins, lipids, and other molecules released by cells. In this context, it plays a crucial role in cell-to-cell communication and signaling, which directly impacts tissue regeneration.
The researchers’ findings reveal that tissue-mimetic culture significantly improved the regenerative activity of keratinocytes and fibroblasts in vitro. Keratinocytes are the primary cells found in the outermost layer of the skin, while fibroblasts are responsible for the production of the extracellular matrix and collagen, which are vital for tissue repair and healing.
These promising results suggest that the application of tissue-mimetic culture could lead to more effective therapies for wound healing and tissue repair, benefiting patients suffering from chronic wounds, burns, and other injuries. As a next step, the researchers plan to further investigate the potential of tissue-mimetic culture in in vivo settings and explore its clinical applications in regenerative medicine.
For more information, please contact:
- Trice Alford
- Chief Marketing Officer
- [email protected]
About
Ronawk’s Bio-Block Universe™ is the first expandable Bio-Factory designed to accelerate the development of biotechnology applications, processes, and technologies. By leveraging advanced mimetic culture technology, Ronawk’s Bio-Block Universe™ streamlines cell and tissue production, ultimately expediting research for next-generation therapies.
The Bio-Block Universe™ simplifies the once-tedious process of mimetic-culture workflows by minimizing labor, consumables, and space. Bio-Block™ technology employs biomimicry of soft tissues to optimize the growth of cells outside the body in a way that closely mirrors their natural growth within the body. This approach not only increases biological opportunities but also ensures cell viability, preservation of key characteristics, and secretion of therapeutic biologics. The process also lowers senescence and risks of contamination by removing subculturing from the process.
Ronawk’s Bio-Block™ platform is customizable, offering consistent, repeatable, and scalable bio-mimetic microenvironment production that accelerates research and paves the way for innovative regenerative therapies. By harnessing the power of mimetic culture technology Ronawk is committed to transforming the field of biotechnology and advancing the development of life-changing treatments for patients in need.
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