Inspired by the acquisition of Cord Blood Registry by AMAG Pharmaceuticals for $700M in June of 2015, this post considers five cord blood investors that are impacting the global marketplace.  It includes traditional investments, acquisitions, and contributions from wealthy founders. If you are operating within the cord blood industry, you need to know these market investors. [Read more…]
Key Dates in the Discovery of Mesenchymal Stem Cells (MSCs)
Mesenchymal stem cells (MSCs) have inspired a great deal of activity as a novel therapeutic approach. Presently, MSC-based clinical trials are being conducted for a variety of disease conditions, with many trials demonstrating safety and efficacy.
Clinical utility of MSCs can be attributed to four key biological properties:
- Their potential to migrate to sites of inflammation caused by tissue injury when injected intravenously
- Their potential to differentiate into different cell types
- Their potential to release different bioactive molecules that can stimulate the recovery of injured cells
- Their ability to modulate inflammation and accomplish immunomodulatory functions
Currently, several hundred MSC clinical trials are in progress across different parts of the world, including within the U.S. European Union (EU), China, Middle East, and South Korea. Among these clinical trials, approximately one-third are exploiting MSCs for various disease indications. Unfortunately, only a small number of clinical trials using MSCs have reached Phase III, indicating that the therapeutic potential for MSCs has yet to be realized.
One of the major bottlenecks to the industry is how to manufacture clinical-grade MSCs on a commercial scale, which Australian regenerative medicine company Cynata Therapeutics (ASX:CYP) is aiming to solve.
To fully understand the cell type and its evolution over time, this post considers key dates in the discovery of mesenchymal stem cells (MSCs). [Read more…]
Positive Data from Cynata MSCs in Second Preclinical Asthma Study
- Clear efficacy data for Cynata’s proprietary Cymerusâ„¢ MSCs in second preclinical study in a clinically-relevant model of asthma
- Cymerus MSCs caused significantly greater reduction of airway hyperresponsiveness compared to corticosteroid treatment
- Data suggest Cymerus MSCs can be administered alone or in combination with corticosteroids to treat the airway hyperresponsiveness associated with asthma
- Completion of this study will further advance the path towards clinical trials
MELBOURNE, Australia, Aug. 23, 2017 — Australian stem cell and regenerative medicine company, Cynata Therapeutics Limited (ASX:CYP), is pleased to announce further highly promising data supporting the efficacy of its proprietary Cymerusâ„¢ mesenchymal stem cells (MSCs) in a second preclinical asthma study.
The study was conducted under the supervision of Associate Professor Samuel and Dr Simon Royce of the Monash Lung Biology Network,1 focusing on the effects of CymerusTM MSCs in combination with or in comparison to the corticosteroid dexamethasone, which is commonly used to treat exacerbations of asthma in human patients. The study used a well-established mouse model of chronic allergic airways disease that closely resembles asthma in humans. This part of the study focused on airway hyperresponsiveness (AHR), which is a key clinical manifestation of asthma. [Read more…]
Major Milestone for Stem Cells – 300K Scientific Publications
Wow, this is a big moment for the stem cell community. We officially crossed 300,000 stem cell publications released to PubMed.gov. PubMed is a service of the U.S. National Library of Medicine and NIH that comprises more than 27 million citations for biomedical literature.[1] It is the largest and comprehensive global database that exists for scientific publications. [Read more…]
Celularity Accelerates Breakthrough Placental Discovery & Therapeutic Platform
New Biotechnology Company Accelerates the Delivery of Transformative Innovations in Treatments of Cancer, Inflammatory & Degenerative Diseases, and Functional Regeneration
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