If absent, the condition may not be referred to cancer at all, but rather labeled as “idle”. In such instances the patient may be monitored rather than immediately directed to therapy to be on the safe side. If therapy was needed, the same information may be used to determine which therapies would be effective rather than a “try and see” approach.
Moncton’s Dr. Steve Griffiths with Michelle Cormier (Atlantic Cancer Research Institute, now RCMP Ottawa) developed a type of molecular double-sided sticky tape they call Venceremin peptides that cross-link chaperones and cause the medically important exosomes to settle out from the sea of other similar particles, a process given some help by a quick spin in a laboratory centrifuge. Free of background, the exosomes can be examined more closely, free of dilution and interference.
Dr Aled Clayton, an internationally renowned expert on exosomes at Cardiff Medical School in the U.K., confirmed that Dr. Griffiths idea worked on both laboratory and clinical samples quickly and easily. The captured exosomes are so tightly held in a net-like postage bag formed by peptide cross linkage, that it is possible to rinse the deposits to further wash away interfering materials that interfere with standard laboratory tests. It is simple and only takes an hour.
The approach may provide a substantial boost to existing medical tests troubled by background and poor sensitivity and further empower the age of precision medicine.