Using HLA “Super Donors”, ORIG3N’s Crowdsourced Cell Repository Contains Donor Matches for 90% of U.S.

ORIG3N announced it has identified “super donor” matches for 90 percent of the U.S. population. The discovery will accelerate how quickly and successfully we match people for transplants, as tissue can be generated from these cells. ORIG3N was able to achieve this milestone approximately 5x faster than its Japanese counter parts because it has built the world’s largest crowdsourced cell repository called LifeCapsule.

HLA is short for “human leukocyte antigen.” It is a gene complex encoding the cell-surface proteins that control regulation of the human immune system. More simply, it is a protein found on most cells of your body that determines how your body recognizes what is you versus other.

HLA “super donors” are people with tissues that are immunologically compatible with a large percentage of the human population. They are very rare in the population, making them difficult to identify.

The signficanceof this announcement by ORIG3N is that for the first time in history, a complete set of matched samples has been identified and can be industrially produced. Utilizing induced pluripotent stem cell (iPSC) technology, any of the 200+ tissues that compose the human body can now be created.

Importantly, these tissues would be an exact match to the individuals requiring them, even though they were derived from another person (an allogenic transplant).

According to ORIG3N, in the near future, this approach may allow people to rapidly get an exact match for a transplant, instead of waiting for months. Instead, tissues could be “pre-produced.”

For more information, visit www.orig3n.com.