Cantanhede, Portugal, March 2, 2022 – Exogenus Therapeutics is proud to announce a new research collaboration with Boehringer Ingelheim to explore the use of extracellular vesicles as therapeutic tools for regenerative medicine. This joint effort led by Boehringer Ingelheim’s Research Beyond Borders (RBB) Unit focuses on pre-clinical testing of Exogenus Therapeutics’ lead candidate Exo-101, in various regenerative medicine indications.
Exo-101 is enriched in extracellular vesicles secreted by pre-conditioned umbilical cord blood mononuclear cells, which exhibit immunomodulatory and regenerative properties1,2, and a safe toxicological profile3 demonstrated in preclinical studies.
Joana Correia, CEO of Exogenus Therapeutics emphasized “We are delighted to partner with Boehringer Ingelheim in this endeavor, in the hope of unlocking new options for more patients with unmet needs. Our previous work with Exo-101 demonstrates a context-dependent multifactorial mechanism of action, which supports its use for the treatment of different diseases. Exploring natural extracellular vesicles as therapeutic alternatives is an innovative approach that has the potential to change the current paradigm of medicine, by inducing the intrinsic potential for organ regeneration and to accelerate the reach of exosomes to patients in need.”
About Exogenus Therapeutics
Exogenus Therapeutics is an early-stage R&D company dedicated to the development of innovative products using naturally derived extracellular vesicles. Its lead product Exo-101 is recognized as a major advancement in the field of exosome-based therapeutics, and as a reference for an alternative clinical use for umbilical cord blood. Leveraging on its experience, Exogenus Therapeutics’ mission is to foster a new era of extracellular vesicle-based solutions to solve major healthcare challenges, through internal and collaborative R&D.
References
1. Cardoso RMS, Rodrigues SC, Gomes CF, et al. Development of an optimized and scalable method for isolation of umbilical cord blood-derived small extracellular vesicles for future clinical use. Stem Cells Transl Med. 2021;10(6):910-921. doi:https://doi.org/10.1002/sctm.20-0376<
2. Rodrigues SC, Cardoso RMS, Freire PC, et al. Immunomodulatory Properties of Umbilical Cord Blood-Derived Small Extracellular Vesicles and Their Therapeutic Potential for Inflammatory Skin Disorders. Int J Mol Sci. 2021;22(18):9797. doi:10.3390/ijms22189797<
3. Rodrigues SC, Cardoso RMS, Gomes CF, et al. Toxicological Profile of Umbilical Cord Blood-Derived Small Extracellular Vesicles. Membranes (Basel). 2021;11(9):647. doi:10.3390/membranes11090647