Gosselies, Belgium, July 15, 2024 – EXO-Harvest, an affiliate of convEyXO, is thrilled to announce the successful launch of its cutting-edge multi-scale bioreactor platform for adherent cells and extracellular vesicles (EVs) production, in partnership with IPRATECH. The platform is now fully operational, marking a significant milestone in joint efforts to advance biotechnological solutions through engineering excellence.
EXO-Harvest’s launch of the breakthrough multi-scale bioreactor platform will help overcome the challenges of MSC and EV manufacturing, to make therapies “triple A” from day one —Available, Accessible, and Affordable.
EXO-Harvest created 2 versions: a small-scale multi-bioreactor for process development and a mid/large scale bioreactor for clinical lot production.
The small scale multi-parallel screening platform offers a cost-efficient way for process development of cells and EVs production from small to mid-scales for full industrialization. The automated and integrated system enables rapid optimization of all critical parameters such as culture media and refreshment strategies, fixed beds and their geometries, fluidics and kinetics, among others.
ConvEyXO successfully integrated this innovative multi-scale bioreactor platform, utilizing EXO-Harvest as an enabler to progress, in a cost-efficient way, towards clinical product development and industrialization. With EXO-Harvest’s multi-scale bioreactor platform as an enabler, convEyXO advances its anti inflamm-aging therapeutic product development reducing the cost and time, while optimizing the EV production of their WJ-iMSC’s and achieving a 1010 EV/cm2 of adherence with the custom fixed bed bioreactor.
Based on convEyXO WJ-iMSC cell line and EXO-Harvest manufacturing capabilities, convEyXO can consider producing batches with unprecedented homogeneity and affordability.
About EXO-Harvest
EXO-HARVEST, an affiliate of convEyXO, is dedicated to developing technologies in the field of mesenchymal stem cells (MSCs) and extracellular vesicles (EVs). EXO-HARVEST has developed multi-scale bioreactor platform to industrialize the manufacturing of adherent cells and extracellular vesicles using 3D printed fixed beds. The platform offers scalability from screening – for process development in a cost-efficient way – up to industrialization.
About convEyXO
ConvEyXO is committed to a healthier lifespan through the development of an anti inflamm-aging and anti-inflammatory therapeutic portfolio, addressing high-prevalence unmet medical needs by unlocking the transformative power of extracellular vesicles (EVs). By focusing on the industrialization of EV manufacturing using a 3D printed fixed bed, convEyXO aims to revolutionize this field.
About IPRATECH
IPRATECH is dedicated to advancing biotechnological solutions through engineering excellence.
Thanks to IPRATECH’s collaboration, we have successfully integrated the fixed bed in the manufacturing process, turning our vision into reality. Thank you, IPRATECH, for the exceptional collaboration.
For more details, visit this LinkedIn post or watch the video below.
