October 25, 2016 – 12:00 PM EST
Groundbreaking experimentation in 2006 led to the introduction of induced pluripotent stem cells (iPSCs). These are adult cells which are isolated and then transformed into embryonic-like stem cells through the manipulation of gene expression, as well as other methods. Research and experimentation using mouse cells by Shinya Yamanaka’s lab at Kyoto University in Japan was the first instance in which there was successful generation of iPSCs.
In 2007, a series of follow-up experiments was done at Kyoto University in which human adult cells were transformed into iPSCs. Nearly simultaneously, a research group led by James Thomson at the University of Wisconsin-Madison accomplished the same feat of deriving iPSC lines from human somatic cells.
In the 10 years since their discovery, induced pluripotent stem cells have transformed our toolkit for studying human development and disease. As the field enters its next decade, a new wave of innovative technologies, such as CRISPR/Cas9-based genome editing, organoid culture, and single-cell omics, have converged with iPSCs to yield new insights for their use in stem cell engineering and therapeutic discovery.
Join us on October 25th at 12:00 PM EST for exciting presentations from our speakers Guo-Li Ming of Johns Hopkins University and Charles Gersbach of Duke University on how these novel advanced technologies are being applied in iPSCs to generate better models for studying and treating human disease. [Read more…]